First, adult female heartworms release their young, called microfilariae, into an animal's bloodstream. Then, mosquitoes become infected with microfilariae while taking blood meal from the infected animal. During the next 10 to 14 days, the microfilariae mature to the infective larval stage within the mosquito. After that, the mosquito bites another dog, cat or other susceptible animal, and the infective larvae enter through the bite wound. It then takes a little over 6 months for the infective larvae to mature into adult worms. In dogs, the worms may live for up to 7 years. Microfilariae cannot mature into adult heartworms without first passing through a mosquito.
For both dogs and cats, clinical signs of heartworm disease may not be recognized in the early stages, as the number of heartworms in an animal tends to accumulate gradually over a period of months and sometimes years and after repeated mosquito bites.
Recently infected dogs may exhibit no signs of the disease, while heavily infected dogs may eventually show clinical signs, including a mild, persistent cough, reluctance to move or exercise, fatigue after only moderate exercise, reduced appetite and weight loss.
Cats may exhibit clinical signs that are very non-specific, mimicking many other feline diseases. Chronic clinical signs include vomiting, gagging, difficulty or rapid breathing, lethargy and weight loss. Signs associated with the first stage of heartworm disease, when the heartworms enter a blood vessel and are carried to the pulmonary arteries, are often mistaken for feline asthma or allergic bronchitis, when in fact they are actually due to a syndrome newly defined as Heartworm Associated Respiratory Disease (HARD).
Heartworm infection in apparently healthy animals is usually detected with blood tests for a heartworm substance called an "antigen" or microfilariae, although neither test is consistently positive until about seven months after infection has occurred.
Heartworm infection may also occasionally be detected through ultrasound and/or x-ray images of the heart and lungs, although these tests are usually used in animals already known to be infected.
Heartworm prevention is safe, easy and inexpensive. While treatment for heartworm disease in dogs is possible, it is a complicated and expensive process, taking weeks for infected animals to recover. There is no effective treatment for heartworm disease in cats, so it is imperative that disease prevention measures be taken for cats.
There are a variety of options for preventing heartworm infection in both dogs and cats, including monthly tablets and topicals. These methods are extremely effective, and when administered properly on a timely schedule, heartworm infection can be completely prevented. These medications interrupt heartworm development before adult worms reach the lungs and cause disease.
Usually, all but the most advanced cases of heartworm disease can be successfully treated in dogs. Currently, there are no products in the United States approved for the treatment of heartworm infection in cats. Cats have proven to be more resistant hosts to heartworm than dogs, and often appear to be able to rid themselves of infection spontaneously. Unfortunately, many cats tend to react severely to the dead worms as they are being cleared by the body, and this can result in a shock reaction, a life-threatening situation. Veterinarians will often attempt to treat an infected cat with supportive therapy measures to minimize this reaction; however it is always best to prevent the disease.
Adult heartworms in dogs are killed using a drug called an adulticide that is injected into the muscle through a series of treatments. Treatment may be administered on an outpatient basis, but hospitalization is usually recommended. When the dog is sent home, exercise should be limited to leash walking for the duration of the recovery period, which can last from one to two months. This decreases the risk of partial or complete blockage of blood flow through the lungs by dead worms.
Re-infection during treatment is prevented by administration of a heartworm preventive. These preventives may also eliminate microfilariae if they are present. Dogs in heart failure and those with caval syndrome require special attention.
|Parasite||Dirofilaria immitis||Dirofilaria immitis|
|Susceptibility to infection||Lower than dogs - 61% to 90% of cats exposed to infective larvae become infected||Very high - virtually 100% of dogs exposed to infective larvae become infected|
|Longevity of worms||2-3 years||5-7 years|
|Ectopic infections||Not uncommon||Occasionally|
|Number of worms||Usually less than 6, 1-2 worms most common||Not uncommon to find more than 30|
|Single-sex infections in meso- to high-endemic areas||Common||Unusual|
|Organ with greatest pathology||Lungs||Heart and lungs|
|Clinical importance of small worm burdens||Potentially fatal||Clinical importance depends on the size of the dog, the size of the worm burden, and exercise level|
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